The familiar Mario Hero is back but this time there is no princess to rescue and any enemies to defeat that you will control him as a doctor. Your task is to control the pills fall into a suitable position to eliminate stubborn viruses. The pills can have one or two colors before they fall you can rotate 90 degrees to the right or left. When the pills are the same color as the viruses or other pills and form a vertical or horizontal line from four squares, they disappear. When all the viruses in the playground are destroyed, the game will be completed. Otherwise, if you fill the playground with the pills, you will lose.