The next installment in the Guilty Gear science-fiction fighting series, in which bio-weapons are known as Gears battle for supremacy and survival while evading the so-called Holy Knights who seek to eradicate them.
As in previous series installments, characters engage in tournament-style combat using their unique abilities and techniques. In GG Isuka, however, the confrontations are 2-on-2 instead of 1-on-1, occur in multi-plane arenas (similar to Fatal Fury), and require manual orientation switching.
Two new playable characters, new backgrounds, and game modes have been added, including the “Boost” mode, which transforms the game into a 2D side-scrolling beat-them-up.